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Chimeric orthopoxvirus

WebJun 6, 2024 · CF33-hNIS Infects, Replicates in, and Kills Colon Cancer Cells. Chimerization and high-throughput analysis yielded a successful chimeric orthopoxvirus candidate that resulted in superior cell killing and viral replication when compared with parental strains, as previously reported.14, 15, 16 Insertion of hNIS at the tk locus (Figure 1 A) resulted in … WebOrthopoxvirus (OPV) is a genus of closely related, large DNA viruses that encode about 200 genes. OPV includes some pathogenic species with strict host restriction such as …

A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety ...

WebJun 2, 2024 · CF33-hNIS-anti-PD-L1 (CHECKvacc) is a novel chimeric orthopoxvirus with robust anti-cancer activity in TNBC xenografts. Cells infected with CHECKvacc were shown to express functional human sodium-iodide symporter (hNIS) and anti-PD-L1 proteins. hNIS gene transfer allows tracking of virus by 99mTc single-photon emission computed … WebCF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust preclinical activity ... launchpad youth services https://balbusse.com

Novel Chimeric Immuno-Oncolytic Virus CF33-hNIS-antiPDL1 for ... - LWW

WebSep 25, 2024 · Anthony K. Park et.al utilized an oncolytic chimeric orthopoxvirus carrying a CD19t-encoding gene to infect solid tumor cells including those of pancreatic cancer, prostate cancer, and breast cancer. They demonstrated that OVs can effectively deliver the CD19-CAR target to solid tumors and upregulate the expression of CD19t on the surface … WebApr 26, 2024 · Detailed Description: CF33-hNIS, a novel chimeric orthopoxvirus, will be administered as a monotherapy or in combination with pembrolizumab to assess the … WebFor these studies, we used an oncolytic chimeric orthopoxvirus, designed to infect a large spectrum of tumors (13) (14)(15)(16)(17), carrying CD19t under the control of the vaccinia synthetic ... launchpage.org chome

Orthopoxvirus - Wikipedia

Category:Oncolytic viruses for triple negative breast cancer and beyond

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Chimeric orthopoxvirus

Novel Chimeric Immuno-Oncolytic Virus CF33-hNIS-antiPDL1 …

WebCF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against 5 PDAC cell lines was tested at various doses (multiplicity of infection [MOI] = 0.01, 0.1, 1, 10). WebApr 28, 2024 · One hundred chimeric orthopoxvirus plaques were picked from CV-1 cells infected with the chimeric orthopoxvirus pool. These 100 plaques were further plaque purified two more times in CV-1 cells to …

Chimeric orthopoxvirus

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WebSep 9, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity.23, 24, 25 CF33 has a mutation in the J2R (thymidine kinase [TK]) gene, and hence it depends on the cellular pool of thymidine triphosphate. WebJul 6, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity. 23 O’Leary M.P.

WebSep 25, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity. 23, 24, 25 CF33 has a mutation in the J2R (thymidine kinase [TK]) gene, and hence it depends on the cellular pool of thymidine triphosphate. WebApr 28, 2024 · Chimeric Orthopoxvirus CF33 Effectively Kills TNBC In Vitro CF33 demonstrates both time- and dose-dependent cytotoxicity against four different TNBC cell lines. In the BT549, Hs578T, and MDA …

WebCF33-hNIS, a novel chimeric orthopoxvirus, will be administered as a monotherapy or in combination with pembrolizumab to assess the safety and efficacy of the treatment … WebNational Center for Biotechnology Information

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launchpad york st johnWebFeb 4, 2024 · CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against five PDAC cell lines was tested at various doses (multiplicity of infection (MOI) = 0.01, 0.1, 1, 10). Production and … launch page edgeWebAug 15, 2024 · Introduction and Objective: CF33-hNIS is a novel, chimeric orthopoxvirus with robust anti-tumor activity at relatively low titers and with a low multiple of infectivity (MOI) in a variety of pre-clinical models. This is a Phase 1, open-label, dose escalation study in adult patients with selected advanced or metastatic solid tumors to evaluate the safety … justice wilson muskWebJun 29, 2024 · One hundred chimeric orthopoxvirus plaques were picked from CV-1 cells infected with the chimeric orthopoxvirus pool. These 100 plaques were further plaque purified two more times in CV-1 cells to yield 100 clonally purified individual chimeric virus isolates, which, together with the parental viruses, were subjected to high-throughput ... launch page websiteWebOrthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae.Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. … launch parameters powerappsWebApr 26, 2024 · Novel chimeric orthopoxvirus isolates CF33 and CF17 show superior cancer cell killing capability compared to the parental individual wild-type virus strains. Fifty-four solid cancer cell lines in ... launch page org malware bytesWebApr 1, 2024 · Study Design. CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against 5 PDAC cell lines was tested at various doses (multiplicity of infection [MOI] = 0.01, 0.1, 1, 10). justice wine