WebJun 6, 2024 · CF33-hNIS Infects, Replicates in, and Kills Colon Cancer Cells. Chimerization and high-throughput analysis yielded a successful chimeric orthopoxvirus candidate that resulted in superior cell killing and viral replication when compared with parental strains, as previously reported.14, 15, 16 Insertion of hNIS at the tk locus (Figure 1 A) resulted in … WebOrthopoxvirus (OPV) is a genus of closely related, large DNA viruses that encode about 200 genes. OPV includes some pathogenic species with strict host restriction such as …
A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety ...
WebJun 2, 2024 · CF33-hNIS-anti-PD-L1 (CHECKvacc) is a novel chimeric orthopoxvirus with robust anti-cancer activity in TNBC xenografts. Cells infected with CHECKvacc were shown to express functional human sodium-iodide symporter (hNIS) and anti-PD-L1 proteins. hNIS gene transfer allows tracking of virus by 99mTc single-photon emission computed … WebCF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust preclinical activity ... launchpad youth services
Novel Chimeric Immuno-Oncolytic Virus CF33-hNIS-antiPDL1 for ... - LWW
WebSep 25, 2024 · Anthony K. Park et.al utilized an oncolytic chimeric orthopoxvirus carrying a CD19t-encoding gene to infect solid tumor cells including those of pancreatic cancer, prostate cancer, and breast cancer. They demonstrated that OVs can effectively deliver the CD19-CAR target to solid tumors and upregulate the expression of CD19t on the surface … WebApr 26, 2024 · Detailed Description: CF33-hNIS, a novel chimeric orthopoxvirus, will be administered as a monotherapy or in combination with pembrolizumab to assess the … WebFor these studies, we used an oncolytic chimeric orthopoxvirus, designed to infect a large spectrum of tumors (13) (14)(15)(16)(17), carrying CD19t under the control of the vaccinia synthetic ... launchpage.org chome