WebUsing virus-specific CD8 T cells and human hepatocytes, we analyzed the modulation of virus-specific CD8 T-cell function after recognition peptide-pulsed or virally infected hepatocytes. We observed that hepatocyte antigen presentation was generally inefficient, and the quantity of viral antigen strongly influenced CD8 T-cell antiviral function. Web15 jul. 2001 · Ag presentation by liver non-bone marrow-derived cells was responsible for most of the accumulation of activated CD8 + T cells. In contrast, Ag presentation by bone marrow-derived cells resulted in less accumulation of T cells in the liver, but a higher frequency of apoptotic cells within the intrahepatic T cell population.
Antigenpresentatie - Celbiologie en immunologie - StudeerSnel
Web25 okt. 2010 · Hepatocyte DNA released from damaged cells has been identified as an endogenous ligand of TLR9 that promotes mDCs to secrete IL-10 (Ref. 60 ), which decreases the production of IL-6, TNF and... Web50. ]. Thus, in the liver, both antigen-specific lymphocyte receptors and pattern recognition receptors are exposed to their ligands. The liver contains a diverse population of both adaptive and innate immune cells. T cells are abundant, with a bias towards CD8+ T cells, and activated T cells predominate [. 17. porthkerry country park opening times
Antigen-presenting cell function in the tolerogenic liver
Web11 mei 2009 · These possibilities are not mutually exclusive, and it is not clear whether species differences in hepatocyte antigen presentation exist as well. We have also shown that both AAV vectors containing DNA and empty capsid particles were able to sensitize hepatocytes for cytolysis, but only the former is capable of mediating gene transfer. WebAlthough antigen presentation was modest, it was sufficient to flag transduced cells for CTL-mediated lysis in an in vitro killing assay. Destruction of hepatocytes was inhibited … Web2 jul. 2007 · Hepatocytes express CD1d and present lipid antigens to NKT cells. Depletion and dysregulation of hepatic NKT cells occurs in mice with fatty livers. Herein, we assess whether reduced CD1d content... porthkerry gp