Web12 de fev. de 2024 · Chronic hypoxia is related to the pathogenesis of NASH. HIF-2α is the key gene for lipid metabolism, fibrosis, and inflammation in many cells. To identify the … Web20 de mar. de 2008 · HIF-1α, a master regulator for hypoxia-inducible gene expression, regulates gene expression to promote energy production as well as oxygen delivery in response to hypoxia. 14–16 HIF-2α, also known as endothelial PAS domain protein 1 (EPAS1), has many similarities with HIF-1α. 17–19 However, several molecular, …
HIF-2α - a mediator of osteoarthritis? Cell Research - Nature
Web22 de jul. de 2024 · Sodium/glucose cotransporter 2 (SGLT2) inhibitors exert important renoprotective effects in the diabetic kidney, which cannot be readily explained by their actions to lower blood glucose, blood pressure, or glomerular filtration pressures. Their effects to promote erythrocytosis suggest that these drugs act on hypoxia-inducible … Web6 de out. de 2024 · Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T … oyo winter garden
The role of hypoxia‐inducible factor‐2 alpha in angiogenesis
Web12 de fev. de 2024 · Chronic hypoxia is related to the pathogenesis of NASH. HIF-2α is the key gene for lipid metabolism, fibrosis, and inflammation in many cells. To identify the molecular mechanism through which hypoxia exposure increases the morbidity of NASH, the expression level of HIF-2α was analysed and was found to be upregulated in human … WebJuanjuan Chen, Raouf A. Khalil, in Progress in Molecular Biology and Translational Science, 2024. 6.3 Hypoxia-Inducible Factor. HIF is a transcriptional factor that plays a role in the physiologic responses to hypoxia. HIF-1 is a heterodimer consisting of an oxygen-regulated HIF-1α and HIF-2α subunits and a constitutively expressed HIF-1β subunit. Web19 de set. de 2024 · We deleted HIF-2α in the NP tissue using a notochord-specific FoxA2 Cre allele to study HIF-2α function in the adult intervertebral disc. Unlike observations in HIF-1α cKO mice, fate mapping studies using Rosa26-mTmG reporter showed that HIF-2α loss in NP did not negatively impact cell survival or affect compartment development. oyo yakuri pharmacometrics