Proteasome inhibitor lactacystin
WebbDescription. Cell-permeable, potent and selective proteasome inhibitor. (2R,3S,4R)-3-Hydroxy-2- [ (1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester. A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N ... WebbLactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). 体内活性 After injection in young and adult mice, Lactacystin (microinjection; 2 μg) causes a Parkinson's disease-like motor phenotype 5-7 days [2].
Proteasome inhibitor lactacystin
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WebbPDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). … Webb22 apr. 2015 · A succinct review of proteasome inhibitors used in proteasome research, and survey result from the literature. 蛋白酶体及其抑制剂 蛋白酶体是蛋白质合成过程中错误折叠的蛋白和其他蛋白被proteolyzed的主要降解途径。 它存在于所有的真核细胞、古细菌和一些细菌中，是一种具有多重催化活性的蛋白酶，由多个催化和调节蛋白组成。 它具 …
Webb7 dec. 2011 · 这样的话，lactacystin可抑制泛素依赖的和非泛素依赖的蛋白酶体降解，而MG132只能抑制泛素依赖的蛋白酶体降解，我觉得这才是比较重要的差别。. 其实在实验上，对我们最重要的区别是： 它们对有的蛋白work，对某些蛋白不work。. 有些蛋白对MG132不敏感，对 ... WebbShuhong Lei is an academic researcher. The author has contributed to research in topic(s): Topoisomerase & Small interfering RNA. The author has an hindex of 2, co-authored 2 publication(s) receiving 190 citation(s).
Webb18 apr. 2012 · A distinct type of proteasome inhibitor is lactacystin, a Streptomyces metabolite, which selectively inhibits multiple peptidase activities of mammalian proteasomes by covalently modifying the ... Webb14 apr. 2024 · ATXN3 is a ubiquitously expressed deubiquitinating enzyme (DUB) that regulates many cellular processes including proteasome and autophagy-mediated protein degradation, transcription, cytoskeletal dynamics, and DNA damage repair ( Costa Mdo and Paulson, 2012; Da Silva et al., 2024; Matos et al., 2024 ).
WebbThe proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated …
WebbLactacystin (1) (Fig. 11.4) is a metabolite obtained from a Streptomyces bacterial strain, and was the first proteasome inhibitor found to have antimalarial activity. Although it … breast milk fortified with formulahttp://www.stemcell8.cn/thread-47148-1-1.html cost to replace a tub with a walk in showerWebb14 apr. 2024 · Similar to our results in aged Atxn3 KO mouse cerebella, MEFs derived from Atxn3 KO mice (Reina et al., 2010) treated with the proteasome inhibitor lactacystin … cost to replace audi q7 windshieldWebbLactacystin, a proteasome inhibitor: discovery and its application in cell biology. Lactacystin was isolated from the culture broth of Streptomyces lactacystinaeus as an … breast milk fortifier bombsWebb17 mars 2003 · effects of a transcription inhibitor, the proteasome inhibitor lactacystin, on ECAM expression and myeloid (HL60) cell adhesion to human umbilical vein endothelial cells (HUVEC) activated by concurrent, sequential, and long-term (24 h) treatment with IL-1 and TNF- . We show, for the first time, that lactacystin inhibits 1) 4-h concurrent IL-1 ... cost to replace auto window regulatorWebbProduct name Lactacystin, proteasome inhibitor Description Cell-permeable, potent and selective proteasome inhibitor Biological description Potent, irreversible, cell-permeable, … cost to replace auto headlinerWebb2 mars 1999 · However, the proteasome inhibitors MG132 or lactacystin significantly inhibited the UBA/UBC-mediated degradation of ER. These data are consistent with our … cost to replace automatic pool cover